Health & Wellness
NIH’s Genome Chief Says Genomics Is Evolving and Doctors Need Extra Training on It
Researchers proceed to manufacture strides within the topic of genomics, bringing revolutionary treatments and diagnostic instruments to sufferers, whereas suppliers and regulators grapple with the ethical disorders that arise this ability that. As segment of our occasional series of interviews with federal healthcare officials, MedPage This present day Washington Editor Joyce Frieden sat down with Eric Inexperienced, MD, PhD, director of the Nationwide Human Genome Review Institute in Bethesda, Maryland, to chat about his career, basically the most up-to-date advances in genomics, and his hopes for the scheme in which forward for his chosen topic.
The next transcript of the interview, which used to be performed with a public relatives person show, has been edited for length and readability.
Thanks for taking the time to focus on with us! Repeat us about yourself and the scheme in which you ended up for your most up-to-date region.
Eric Inexperienced, MD, PhD: You’re welcome! I used to be born and raised in St. Louis, and then went off to the University of Wisconsin for my undergraduate stage. I came relief to Washington University [in St. Louis] for the MD/PhD program, and then determined to practice in clinical pathology. I had a bit little bit of a vague hobby on this very early topic — molecular diagnostics.
After the principle year, you hurry off and cease postdoctoral analysis 90% of the time, and this used to be in 1988, a year after the note “genomics” used to be coined and a pair of years earlier than the Human Genome Project used to be launched. And I came about to be at Washington University, where there were some world class leaders in genomics. And so I joined one amongst the labs there, and the comfort is history attributable to I form of made a career of it. A year and a half to 2 years into [my postdoc there], the Human Genome Project began and Washington University used to be funded as one amongst the principle genome facilities. I used to be on the entrance line, working one amongst two major initiatives as a postdoc, and within the discontinuance joined the college.
When Francis Collins came here to yell this institute, he [recruited me], so I came here 29 years ago, and for virtually half that time, I’ve been the director.
For your time on the Institute, what progress has been made within the exercise of genomics for diagnosing and treating illness?
Inexperienced: Let’s starting up with most cancers, which is a illness of the genome. After I went to clinical college, so grand of what you did spherical most cancers used to be plug by what segment of the body you decrease it out of. Ought to you decrease it out of the breast, it always situation you down this route, nonetheless within the event you decrease it out of the liver, it be something else, and within the event you decrease it out of a bone, it be something else.
Recently, within the event you ask an oncologist most steadily, “Is it more informative to grab where I decrease it out, or if I gave you a genomic signature of that tumor?,” they wish the signature. On account of what we’re finding out more and more is that that is largely the most intriguing technique to foretell prognosis and decide out basically the most intriguing alternate choices for therapy. The literature is now stuffed with fable after fable of “We found these tumors within the bone and they also ogle admire a breast most cancers and there is now not any major breast most cancers, nonetheless we handled it admire it used to be a breast most cancers and it labored.” So the tissue of starting up do is changing into grand less foremost.
The 2nd example is rare genetic diseases, alongside with some famed ones admire sickle cell, cystic fibrosis, and Huntington’s illness. They’re rather straight forward from a genomic stage attributable to it be assuredly the breakage of a single gene via a mutation in one gene.
When the Genome Project began, we handiest knew about 61 of those diseases for which we knew what gene used to be mutated. Nonetheless now we know virtually 6,000. That has situation up as a circumstance where will bear to you come across a affected person, especially a perplexing affected person — and some folk were undiagnosed for decades — you excellent sequence the genome. It be now not that expensive, lower than $1,000, and the diagnostic yield is going up annually. We’re bettering and greater at figuring this out. Most steadily it supplies you insights on be taught how to accommodate, and customarily it ends a affected person’s diagnostic odyssey — as a minimal they’ve a prognosis.
The third example is with prenatal genetic making an strive out, where they’re largely procuring for faulty chromosomal abnormalities — aneuploidy, admire trisomy 21, famously is called Down syndrome. For that you just are going to like a respectable technique to entry fetal DNA, which [previously] used to be both an amniocentesis or chorionic villus sampling. Both of these is invasive, and I’m told it be now not good, and likewise there is a itsy-bitsy distress of [miscarriage].
What’s varied now? Neatly, biologically, nothing’s varied, nonetheless technologically, all the pieces’s varied. It turns out that the placenta naturally sheds itsy-bitsy quantities of cell-free DNA into the maternal blood. Twenty years ago, we had no ability to detect those teeny bits of DNA that naturally hurry with the waft spherical in maternal blood, nonetheless now we cease attributable to we now bear got new methods for sequencing DNA. So now, the pregnant person gets a blood blueprint, they rob a further tube at 8 to 12 weeks, and they also separate the liquid segment — it has cell-free DNA, some from the fetus and some from Mom. They sequence the DNA exquisitely sensitively and they also excellent ogle for whether or now not all the pieces is uniform. If they detect anything that is largely novel, they’ll repeat it, and ogle more fastidiously, and they also could well cease an amniocentesis.
Here is is called non-invasive prenatal making an strive out, or NIPT. And the industrial sector saw this as a substantial different, so there were more than one firms providing this, and it has pushed the worth down. The obstetrics authentic societies bear talked about here is wide despite the real fact that their members are shedding money, attributable to they realize the test doesn’t wish to be so invasive. As a result, 5 million to 7 million pregnant ladies folk a year worldwide are conception to be getting this non-invasive test.
The fourth do is pharmacogenomics — insist I’m hypertensive and I’m going to rob a hypertensive treatment and I in point of fact bear a series of 10 treatment. Which drug will bear to I rob? It has nothing to cease with the pathophysiology of the hypertension; it has to cease with my drug metabolism pathways and the scheme in which I obvious treatment out of my machine. It will likely be that Drug A, I obvious very poorly so I change into toxic as soon as I rob it, and Drug B I’d “hyper-obvious” so it be couldn’t be effective, and Drug C is one which I obvious completely beautiful so I’m going to defend real via the therapeutic differ. So the foremost distinction is pharmacogenomics.
How are things coming into phrases of clinician consciousness? Are ample doctors attentive to and the utilization of genomics for clinical making an strive out and therapy?
Inexperienced: No, they’re now not, and that is the explanation a wide precedence for the Institute. And we’re working very arduous. It be now not handiest clinical education — it entails the general healthcare starting up ecosystem, which as , oftentimes is now not face to face alongside with your doctor; it be face-to-face alongside with your nurse, your pharmacist, or your doctor assistant. There could be a full team that we want to be transferring alongside. And naturally, we’re doing this at a time where the science is transferring very snappy.
I in point of fact bear a son who is a Third-year clinical pupil. I wish I could well insist that what he realized within the principle 2 years of clinical college used to be ample genomics to be moving for the future that his father’s describing, nonetheless he did now not. And he’s at a prime-fee clinical college. I’m now not faulting the college; here’s a arduous distress for them. We won’t excellent insist, “Medical colleges, it be your distress,” attributable to making an strive to trade the clinical college curriculum is admire making an strive to trade the federal government. Nonetheless these students are vivid, lifelong learners, so we now bear got to position out the instruments to abet them be taught genomics as they hurry alongside.
No longer to mention the real fact that heaps of physicians out there, alongside with my clinical classmates who’re practising treatment, by no scheme heard the note “genomics” as soon as in clinical college, since the note didn’t exist till lawful after they graduated. So it be one amongst the things we’re doing.
I cease mediate more and more clinicians are changing into wide awake. Extra sufferers with rare diseases are getting referred to clinical specialists or other physicians who cease know about getting the genome sequenced. I used to be told now not too long ago that it used to be conception that within the US, roughly 25,000 sufferers with rare stipulations or suspected rare stipulations will win their genome sequenced annually, and that number can even very correctly be matched internationally.
You’ve got talked about genomics’ progress in making an strive out. What about for therapy of illness?
Inexperienced: It used to be believed that one of the most earliest gene therapy successes would reach with with things which are in blood, and the trigger of that is attributable to bone marrow is available — painful, nonetheless accessible. So let’s discuss two extremes, each diseases where there used to be heaps of hype: sickle cell and cystic fibrosis. And within the case of sickle cell, the tissue where the general motion is, is within the blood, which is made within the bone marrow. In cystic fibrosis there are many organs alive to, nonetheless most seriously the lungs, which are now not very accessible or [easy to culture]. And so it’s intriguing to leer what has performed out.
Ought to you ogle at sickle cell illness, the successes we’re seeing now could well be it’s essential well rob a affected person with sickle cell, rob away some of their bone marrow the utilization of the gene bettering diagram [known as] CRISPR to repair the sickle cell mutation within the laboratory, and then you’re hanging their cells relief in their bone marrow. Then they’re making regular hemoglobin and they also’re cured.
Within the case of cystic fibrosis, there is aloof hope spherical gene therapy, nonetheless in point of fact the things which bear created progress in most up-to-date years were the reach of most up-to-date treatment.
Are there guardrails that wants to be place aside spherical this technology?
Inexperienced: I mediate there are some very correctly talked about guardrails spherical genome bettering. It is the adaptation between somatic cells — those are body cells — bone marrow, mind cells, that is all body and that is the explanation beautiful. You’ll want to well cease heaps of stuff with that and it be now not as touching on. It be will bear to you hurry to the germline; that is where the guardrail is. Close now not hurry to the germline, or sperm or egg, and manipulate those. The gentleman in China, he created these twins and made the principle CRISPR infants. The Chinese language are keeping it hush-hush what their fate is, nonetheless there is heaps of reasons to be nervous.
So repeat us about your funds. How wide is it, and what cease you utilize the money on?
Inexperienced: We’re a rather itsy-bitsy institute at NIH, almost definitely within the backside 5 or six in phrases of dimension, despite the real fact that we mediate we now bear got an intellectual footprint that is rock-superstar in phrases of dimension. I mean, genomics is in each insist. Some folk mediate I need to bear 10% or 20% of the NIH funds attributable to genomics is in each insist, nonetheless we’re handiest 1.4% of the NIH funds. It be aloof a wide chunk of trade — about $656 million. Will we would like it’d be greater? Needless to insist, nonetheless by and dapper we now bear had a funds that has allowed us to cease a wide quantity. And we leverage plenty more exercise in attributable to we’re invited to heaps of collaborative initiatives going on in other substances of NIH.
Of that $656 million, 20% of it stays here for a pretty wide on-campus program we now bear got in genetics and genomics. About 5% of it’s to speed the Institute, and 75% goes out to “extramural” grants — we’re giving out grants all at some stage within the world, largely within the US, nonetheless some in another country as correctly. We’re doing all the pieces from creating technologies for sequencing and inspecting DNA, to creating records sources to sharing all this records worldwide, to figuring out how every nucleotide, every unfriendly genome works, and figuring out how variants in our DNA affect our health and illness.
How cease you’re feeling relating to the position that sufferers are playing in directing funding for illness analysis?
Inexperienced: What’s occurring at some stage in all of biomedical analysis — and NIH is main on this as grand as everyone else — is to bring the sufferers into the dialog more. I mediate NIH could well be the principle to insist that for too long, we saved at an arm’s distance from sufferers. And within the discontinuance, that is great now not going to work, in particular for sufferers with rare diseases. And by the scheme in which, this is why they’re aggregating; you’re seeing more and more rare illness communities aggregating together, and that is the explanation what’s main to major programmatic adjustments.
Factual this morning I used to be at a meeting with [one NIH institute director] who spends hours a week having to accommodate varied advocacy groups in [his disease] personnel. I build now not take care of advocacy groups attributable to I build now not obtain any illness. That can perhaps well even be each a blessing and a curse.
Of us on the general elevate concerns relating to privateness in phrases of genetic test results. Is that a insist for you?
Inexperienced: I mediate customarily folk will gash out genetics and fabricate it seem admire it be fully varied in phrases of privateness, and I impress it has some variations attributable to if nothing else, it supplies you insights about your relatives. Nonetheless, there are heaps of different things about you besides genetics, and our clinical files are getting more and more digital. Boy, it’s essential well be taught plenty just a few person excellent by taking a ogle at their clinical files! Of us seem very pondering about any individual seeing their genome sequence, nonetheless they’re less pondering about any individual seeing their clinical files. Deem me, I can cease a considerably greater job of decoding each one amongst these clinical files than decoding their genome on the novel time.
What retains you up at evening?
Inexperienced: I in point of fact bear wide concerns spherical equity, and spherical exacerbating health disparities. We couldn’t be excellent nonetheless one amongst the wrestle cries of the Institute is making genomics mainstream and equitable in treatment. We build now not wish to excellent be mainstream for those that’ve gone to Johns Hopkins or those that win their clinical care at Washington University, nonetheless I mediate relating to the general nooks and crannies of the clinical ecosystem.
Some other one amongst our greatest priorities is to diversify our team. I mean every facet of the genomics team, from a science communicator, to a leader, to a doctor, to a scientist, to a nurse, to a pharmacist — excellent all of it, attributable to we want our entire tent of folk touching genomics to repeat society. In genomics, it be in particular foremost attributable to we excellent build now not mediate we are going to bear interaction the communities and convince everyone to enjoy with genomics as segment of their clinical care except the other folks who they’re talking to resemble them more.
And on the other facet, what makes you angry to pass to work every morning?
Inexperienced: I’m surrounded by terrific folk and I have faith in what we’re doing is changing the world. So I mediate that makes a wide distinction to be with other folks that in point of fact are dedicated and are desirous about what we’re doing.
I hitched my wagon at a in point of fact early stage in my career, with this remarkably vague idea that genomics could well sooner or later trade the practice of treatment. And I guarantee then you definately — which could well were 1988 — or when the Human Genome Project ended twenty years ago, in 2003, I in point of fact did not have faith in I’d seek the fruits of it affecting treatment in any valid scheme in my lifetime. No longer handiest is it in my lifetime, it be whereas I’m aloof professionally active and I win to be assuredly within the pinnacle genomics region within the nation. Factual to bear this occur on my leer, it be ideally suited. It has reach fats circle from an incredibly vague idea of why I wish to cease any of this, to basically in point of fact feel admire I’ve moved the needle.
Thanks all as soon as more for talking with us!
Inexperienced: You’re welcome; reach relief any time!
-
![creator['full_name']](https://clf1.medpagetoday.com/media/images/author/JoyceFrieden_188.jpg)
Joyce Frieden oversees MedPage This present day’s Washington coverage, alongside with reports about Congress, the White Dwelling, the Supreme Courtroom, healthcare trade associations, and federal agencies. She has 35 years of trip covering health coverage. Apply
For many, coffee is an essential part of the day, fueling early mornings, powering through work hours, and providing a comforting ritual. But beyond its well-known ability to wake you up, coffee has some surprising health advantages that make it more than just a tasty beverage.
The Positive Effects of Coffee on Your Health
While excessive consumption can have drawbacks, moderate coffee intake can offer several benefits. Coffee is a complex drink, rich in compounds that contribute to overall well-being.
1. A Natural Energy Booster
The caffeine in coffee acts as a stimulant, enhancing alertness, improving memory, and boosting overall cognitive function. Studies suggest that caffeine can also enhance physical performance by increasing endurance, making it a favorite among athletes and fitness enthusiasts.
2. A Source of Essential Nutrients
Although it may not seem like a significant source of nutrition, black coffee provides small amounts of vital nutrients, including:
- Vitamin B2 (riboflavin): Essential for energy production and overall metabolic function.
- Vitamin B3 (niacin): Helps the body convert food into energy.
- Potassium and Magnesium: Important for maintaining healthy muscle and nerve function.
3. Rich in Antioxidants
Coffee beans are loaded with antioxidants, which help combat oxidative stress and inflammation in the body. Studies suggest that coffee’s health benefits may come from its phenolic compounds, which act similarly to those found in plant-based foods, offering protection at the cellular level.
4. May Reduce the Risk of Type 2 Diabetes
Research has consistently linked regular coffee consumption with a lower risk of developing Type 2 diabetes. Both caffeinated and decaffeinated coffee appear to provide protective effects, likely due to their role in improving insulin sensitivity.
5. Supports Brain Health
Drinking coffee daily may reduce the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Some studies indicate that caffeine plays a role in maintaining brain function as we age, potentially delaying cognitive decline.
6. Promotes Liver Health
The liver is one of the most important organs in the body, and coffee has been shown to support its function. Some research indicates that coffee may reduce the risk of liver diseases such as cirrhosis and fatty liver disease, particularly among individuals who consume it regularly.
7. May Lower the Risk of Certain Cancers
Evidence suggests that coffee drinkers may have a lower risk of developing specific types of cancer, such as liver and colorectal cancer. The protective effect is believed to stem from coffee’s anti-inflammatory properties and ability to promote DNA repair.
8. Mood-Enhancing Properties
Coffee may also positively impact mental health. Some studies have linked regular coffee consumption with a lower risk of depression and anxiety. The caffeine in coffee can enhance mood by increasing the production of neurotransmitters such as dopamine and serotonin.
9. Supports Heart Health
While excessive caffeine intake may raise blood pressure in some individuals, moderate coffee consumption has been linked to a lower risk of cardiovascular issues. Some studies suggest that coffee improves blood vessel function, which may contribute to heart health.
10. Counteracts the Effects of a Sedentary Lifestyle
A recent study suggests that coffee may help mitigate some negative effects of prolonged sitting. Researchers found that individuals who drank coffee regularly experienced a reduced risk of developing chronic conditions associated with inactivity.
Considerations for Coffee Consumption
Despite its many benefits, coffee isn’t a cure-all. To maximize its advantages while avoiding potential downsides, consider the following guidelines:
- Moderation is Key: Experts recommend limiting caffeine intake to around 400 mg per day, roughly three to four small cups of coffee.
- Be Mindful of Additives: Sugary syrups, whipped cream, and excessive milk can turn coffee into a high-calorie indulgence. Opting for black coffee or using natural sweeteners in moderation can keep it healthier.
- Time It Right: Drinking coffee too late in the day can interfere with sleep quality. If you’re sensitive to caffeine, consider avoiding it in the afternoon or evening.
- Pregnancy Considerations: Pregnant individuals are advised to limit caffeine intake to 200 mg per day, as excessive consumption may pose risks.
Enhancing Coffee’s Health Benefits
To make your coffee even more beneficial, consider adding natural spices that boost health benefits:
- Cinnamon: Helps stabilize blood sugar levels.
- Nutmeg: Rich in manganese, which supports metabolism and bone health.
- Cardamom: Contains vitamins and minerals such as calcium, magnesium, and zinc.
- Cocoa Powder: Provides antioxidants, but use it sparingly to avoid excess saturated fat.
The Bottom Line
A daily cup of coffee can do more than just wake you up—it can contribute to long-term health benefits, including lower risks of chronic diseases, improved mental function, and enhanced physical performance. However, balance is essential. Listening to your body, consuming coffee in moderation, and avoiding excessive additives can help you enjoy its perks while maintaining overall well-being.
The social media landscape is on the verge of a major shakeup as Instagram reportedly considers launching a standalone Reels app. This move is seen as a direct response to TikTok’s uncertain future in the United States, where regulatory scrutiny threatens the Chinese-owned platform’s continued operation.
According to a report by The Information, Instagram’s chief Adam Mosseri shared the idea in a recent staff meeting. The proposed Reels app would function independently of Instagram, much like TikTok, offering users a dedicated space for short-form video content. This development aligns with Meta’s broader strategy of capturing market share in the booming short-video sector.
Why a Standalone Reels App?
Instagram’s Reels feature has already gained significant traction within the main app, but Meta sees an opportunity to further solidify its dominance by spinning it off into a separate platform. A standalone Reels app could enhance user engagement, encourage content creators to focus on short videos, and position Meta as a stronger competitor in the short-video ecosystem.
The timing of this move is particularly strategic. The Biden administration has raised concerns over TikTok’s ties to its Chinese parent company, ByteDance, citing national security risks. While TikTok boasts an impressive 170 million U.S. users, ongoing discussions about a potential ban or forced sale have cast a shadow over its future. This uncertainty creates an opening for Instagram’s Reels app to attract users looking for a stable and familiar alternative.
Meta’s History of Short-Video App Experiments
This is not the first time Meta has ventured into the short-video space with a dedicated app. In 2018, the company launched Lasso, an app designed to compete directly with TikTok. However, Lasso failed to gain traction and was shut down in 2020. Despite this setback, Meta remains determined to dominate the short-video space.
In January, the tech giant introduced Edits, a video-editing app aimed at rivaling CapCut, ByteDance’s popular editing tool. This demonstrates Meta’s ongoing commitment to expanding its video offerings and providing creators with robust editing and content-sharing tools.
What would a standalone reels app offer?
If Meta proceeds with launching a separate Reels app, it is expected to build upon the existing success of Reels within Instagram while incorporating new features to enhance the user experience. Some potential offerings include:
- A Dedicated Feed: A Reels-focused app could provide an immersive scrolling experience similar to TikTok, making it easier for users to consume and create short videos without navigating Instagram’s broader ecosystem.
- Advanced Editing Tools: To compete with TikTok’s sophisticated editing features, Meta may introduce enhanced video-editing capabilities, possibly integrating functionalities from its Edits app.
- Monetization for Creators: With TikTok’s uncertain future, Meta could attract top content creators by offering better monetization opportunities through ad revenue sharing and exclusive partnership deals.
- Cross-Platform Integration: The app could allow seamless content sharing between Instagram, Facebook, and Reels, leveraging Meta’s extensive user base.
Can Meta Replicate TikTok’s Success?
While Instagram’s Reels feature has gained popularity, TikTok remains the leader in short-form video content. TikTok’s algorithm, community engagement, and unique cultural influence have made it a dominant force in social media. However, if TikTok faces legal or operational challenges in the U.S., a standalone Reels app could emerge as a strong alternative for users and creators alike.
Meta’s ability to replicate TikTok’s viral content ecosystem will be a key factor in the app’s success. While Instagram has successfully integrated Reels into its existing platform, convincing users to adopt a separate app will require innovative features, strong marketing efforts, and an attractive creator incentive program.
Regulatory Uncertainty and Market Opportunities
The potential ban on TikTok in the U.S. stems from concerns over national security and data privacy. Lawmakers argue that ByteDance’s ownership could allow the Chinese government to access user data and influence public discourse. TikTok has denied these allegations and proposed solutions like U.S.-based data storage to address regulatory concerns. However, the uncertainty surrounding its future presents an opportunity for Meta to capture market share with a Reels-focused app.
At the same time, the move could face regulatory challenges of its own. Meta has been under scrutiny for its market dominance, and launching a standalone Reels app could raise antitrust concerns. Regulators might question whether Meta is using its influence to eliminate competition rather than foster innovation.
What’s Next?
As Instagram and Meta continue to explore the possibility of a standalone Reels app, users and creators will be watching closely. If launched, the app could redefine the short-video landscape and provide a new platform for creative expression. However, success will depend on Meta’s ability to differentiate Reels from TikTok while addressing user needs and regulatory challenges.
For now, Instagram remains tight-lipped about the timeline for this potential launch. But with TikTok’s future in flux, the short-video battleground is heating up, and Meta is ready to make its next move.
Netflix has announced it will not be releasing the highly anticipated documentary about Prince following a new deal made with the late musician’s estate. The collaboration between the estate and Netflix will lead to the development of a new documentary featuring exclusive content from Prince’s archive, ultimately replacing the previously planned release.
Ezra Edelman, known for his acclaimed work on O.J.: Made in America, had spent years working on a nine-hour documentary that was said to include explosive interviews with Prince’s former business partners, lovers, friends, and associates. Reports had suggested that the film would present allegations of physical and emotional abuse, including claims from his ex-partner Jill Jones, who described instances of violence, as well as testimonies from others who recalled Prince’s controlling behavior and his traumatic past.
While the documentary had promised to delve deeply into the complexities of Prince’s life, the new agreement between the Prince estate and Netflix ensures that any narrative presented will be more aligned with the artist’s legacy and wishes. The estate’s goal is to honor Prince’s creativity and genius, ensuring his story is told in a manner that is factually accurate and respectful.
This decision comes after months of controversy surrounding the project, with stakeholders emphasizing the importance of sharing Prince’s story in a way that reflects his profound impact on music and culture. The Prince estate has also hinted at more content coming from his extensive archive, signaling exciting developments for fans and the public to look forward to.
Ariana Grande opened up about her deep connection to Wicked and her strong feelings toward her role as Glinda at a recent FYC event, revealing just how protective she feels about the iconic character. Speaking in a candid conversation, she shared her thoughts on the balance between staying true to the beloved stage musical and adapting it for the screen.
Grande described herself as a “protective nerd,” noting that she felt like the “gatekeeping fan girl” in the room during discussions about the film. She expressed her strong stance on making changes to the musical in a way that still preserved the essence and emotional depth of the story.
“It was important for me to ensure that any changes made had a meaningful reason or emotional connection,” said Grande. Her purist approach was apparent when she discussed the initial plans for the song “Popular,” which had originally included hip-hop drums. She candidly shared how she felt about this idea, saying, “I was like, ‘This cannot happen.’” Grande felt that such a drastic change wouldn’t align with Glinda’s character and wanted to preserve the integrity of the iconic number.
In a playful tone, she added, “How different would life be today if ‘Popular’ had trapped drums in it?” adding that it simply wasn’t the right fit for her character, who is known for her particular rhythm of clapping on one and three.
Grande’s love for the material was matched by the admiration of fellow artist Billie Eilish, who moderated the event. Eilish, who has been a longtime fan of Grande, shared her own excitement for the film and revealed that her personal YouTube account has long been a space for her to express her fandom for Grande. The exchange was filled with warmth, with both women gushing over one another in a way that highlighted their mutual respect and admiration.
When the topic of future acting projects came up, Grande expressed a genuine desire to take on more roles. “I would love that,” she said, reflecting on her ability to explore various creative outlets. For her, the joy of being an artist is being able to wear many different hats and constantly push herself into new creative realms.
With her unwavering commitment to preserving the heart of Wicked, Ariana Grande’s passion for her role as Glinda shines through. Fans of the iconic musical can rest easy knowing that their beloved character is in the hands of someone who is not only a talented performer but a true fan of the material herself.
Olivia Holt is feeling on top of the world after her major studio debut in Heart Eyes, and she’s not shy about sharing the journey. The slasher romcom, directed by Josh Ruben, has garnered rave reviews, marking a perfect next step for Holt after her standout role in Totally Killer (2023). Though her casting came with a unique twist—no chemistry read between her and co-star Mason Gooding—an unforgettable scene helped them quickly bond on set.
Holt and Gooding play two advertising professionals, Ally and Jay, forced to work together on a jewelry company campaign. Their Valentine’s Day dinner takes a wild turn when a traveling serial killer, targeting seemingly happy couples, sets his sights on them. The intense showdown with the “Heart Eyes Killer” escalates quickly, and an early scene in Ally’s bedroom, featuring a comically awkward moment with an intimate bedside object, unexpectedly helped Holt and Gooding find their rhythm together.
As Holt recalls, “It was very early days of shooting, and everyone was still getting acquainted with each other. So it was a nice icebreaker for me, Mason, and the crew, even if it was definitely awkward.” The chemistry on screen was key to the success of the film, and Gooding went the extra mile to bond with Holt by wearing a tank top that read “Olivia Holt’s #1 fan” and even sporting her costume for a day. Holt couldn’t help but laugh as she described the hilarious moment: “He wore my belt and a pair of shorts that were a couple sizes bigger—he was insane.”
Despite their unique start, Holt and Gooding’s collaboration proved to be a hit with audiences, cementing Heart Eyes as one of the most well-received films of the year. Holt’s journey from auditioning for the role of Ally to being on set in New Zealand is a testament to her dedication and the serendipity of the casting process.
In her conversation with THR, Holt also opened up about her audition experience and shared the fun reactions from her co-stars to the film’s memorable jokes. Heart Eyes is a thrilling mix of romance and horror, and Holt’s portrayal of Ally has proven to be the perfect fit in this quirky, high-energy slasher.
The FireAid benefit concert is set to bring together some of the biggest names in the music industry to support the victims of the devastating wildfires that recently swept through Los Angeles. The event will take place on Thursday across two major venues in the city: the Kia Forum and Intuit Dome. The initiative aims to raise funds for rebuilding affected communities and implementing measures to prevent future wildfires.
Why FireAid Matters
The wildfires, which erupted on January 7, caused unprecedented destruction, claiming the lives of around 30 people and levelling nearly 17,000 homes and businesses. The Palisades and Eaton fires were among the most destructive fires in LA’s history, fuelled by strong winds that carried embers for miles, igniting entire neighbourhoods. The proceeds from the concert, along with public donations, will go toward relief and prevention efforts.
Beyond the immediate devastation, these fires have had long-lasting consequences for affected communities. Families have been displaced, local businesses have suffered immense losses, and infrastructure has been severely damaged. With the help of FireAid, efforts will be made to restore these communities, provide necessary aid to those in need, and work toward developing better fire prevention methods to safeguard against similar disasters in the future.
A Spectacular Lineup
The FireAid concert boasts a stellar lineup of over 20 artists from various genres, ensuring a diverse and exciting musical experience. Performances are scheduled at both venues, with acts staggered so audiences can enjoy continuous entertainment.
Performers at Intuit Dome:
- Billie Eilish
- Gracie Abrams
- Jelly Roll
- Katy Perry
- Lady Gaga
- Lil Baby
- Olivia Rodrigo
- Peso Pluma
- Rod Stewart
- Stevie Wonder
- Sting
- Tate McRae
- Earth, Wind & Fire
Performers at the Kia Forum:
- Alanis Morissette
- Anderson .Paak
- Dawes
- Graham Nash
- Green Day
- John Fogerty
- Joni Mitchell
- No Doubt
- P!nk
- Red Hot Chili Peppers
- Stephen Stills
- Stevie Nicks
- The Black Crowes
- John Mayer
Dave Matthews was also scheduled to perform at the Kia Forum but had to withdraw due to a family emergency. Organisers have confirmed that additional surprise guests may also appear throughout the evening.
How to Watch the Event
For those unable to attend in person, the concert will be streamed live across multiple platforms, including Amazon Prime Video, Apple TV, Disney+, Hulu, Facebook, Instagram, Max, Netflix, Tudum, Paramount+, Peacock, NBC News Now, and YouTube. The event will also be broadcast in select AMC and Regal theatres across the United States.
The show kicks off at 6:00 PM in Los Angeles (9:00 PM in New York, 2:00 AM Friday in the UK), allowing global audiences to participate in this philanthropic effort.
How You Can Help
Viewers will have the opportunity to contribute to the relief efforts by making donations via text message or through the official website, FireAidLA.org. Donations will be managed by the Annenberg Foundation, ensuring funds are used for immediate relief as well as long-term fire prevention projects. Additionally, Connie and Steve Ballmer, owners of the LA Clippers, have pledged to match all donations made during the broadcast, doubling the impact of every contribution.
Apart from financial contributions, volunteers and organisations are encouraged to get involved in rebuilding efforts. Local businesses can also support recovery initiatives by offering goods, services, and employment opportunities to those affected by the fires.
Rebuilding and Preventing Future Fires
The funds raised from FireAid will help rebuild homes and businesses lost in the fires while also supporting initiatives aimed at fire prevention. Some of these measures include enhancing early warning systems, improving emergency response strategies, and investing in fire-resistant infrastructure.
Authorities and environmental experts are working on initiatives that focus on sustainable land management, reducing fire-prone vegetation, and implementing controlled burns to minimise the risk of widespread wildfires. Education programs will also be launched to raise awareness about fire safety and encourage communities to adopt fire-preventive measures.
With communities still reeling from the devastation, FireAid serves as a beacon of hope, uniting artists, fans, and philanthropists in an effort to heal and protect the region from future disasters. Whether through attending the event, streaming the concert, or donating, everyone has the opportunity to make a difference.
The collective support of artists, donors, and volunteers is essential in ensuring that LA’s affected communities can rebuild stronger than before. FireAid is not just a concert—it’s a movement aimed at fostering resilience, unity, and long-term recovery for those impacted by these catastrophic fires.
Health
Liang Wenfeng The Visionary Behind DeepSeek Who’s Shaping the AI Landscape and Challenging U.S. Tech Giants
In the fast-evolving world of artificial intelligence (AI), few figures have garnered as much attention as 39-year-old Liang Wenfeng, the founder of DeepSeek. A Chinese AI startup, DeepSeek, is quickly emerging as a key player in China’s ambition to establish self-sufficiency in AI technology. Liang’s leadership represents a shift in China’s approach to technology—from merely adopting innovations from abroad to creating groundbreaking, original AI models that rival the world’s best. With his focus on cultivating innovation and challenging traditional global norms, Liang is spearheading China’s ascent in the AI industry.
A New Era in China’s AI Industry
Liang’s rise to prominence occurred after his participation in a significant event on January 20, 2025. He was one of the nine speakers invited to a closed-door symposium chaired by China’s Premier, Li Qiang. The event brought together academics, government officials, and industry leaders and underscored the growing importance of DeepSeek in the global AI sector. Liang’s youthful presence stood in stark contrast to the older, more established figures around him, signaling a shift in China’s technological leadership. This generational shift not only reflects a change in the country’s tech landscape but also highlights China’s growing self-confidence in its ability to develop world-leading innovations rather than simply follow global trends.
Revolutionizing AI with DeepSeek’s Cutting-Edge Models
Under Liang’s leadership, DeepSeek has introduced AI models that challenge established players like OpenAI and Google DeepMind. Among the most notable of these is DeepSeek-V3, which has been hailed as one of the most advanced AI models to emerge from China. Unlike other AI models that require millions of dollars in computing power, DeepSeek-V3 was trained using less than $6 million in resources—making it up to 50 times cheaper than models developed by U.S.-based companies. DeepSeek’s ability to create high-performing models at such a fraction of the cost has sent shockwaves through the AI industry, with many experts now wondering whether China might soon overtake the U.S. in AI innovation.
Moreover, DeepSeek’s models have demonstrated comparable or even superior capabilities to those of U.S. tech giants. This is particularly important for China, which has historically lagged behind in the AI space when compared to the U.S. and other Western nations. By advancing its own cutting-edge technology, DeepSeek is positioning itself as a competitor to established global leaders in AI, marking a significant shift in the industry.
Championing Open-Source AI for Global Accessibility
One of the most distinctive aspects of DeepSeek’s approach is its commitment to open-source development. Unlike closed-source models, where the technology is proprietary and tightly controlled, DeepSeek has made its AI models openly available to the global tech community. This move has profound implications for the development of AI worldwide, as it allows developers to access, modify, and adapt DeepSeek’s technology for their own applications.
By making its models open-source, DeepSeek is democratising access to AI technology and encouraging innovation across the globe. This stands in contrast to the business practices of companies like OpenAI, which has kept its cutting-edge models proprietary. Liang’s belief in open-source development stems from the idea that it is more than just a business strategy—it’s a cultural practice. He argues that by fostering open-source collaboration, DeepSeek is not only contributing to the advancement of AI but also gaining “soft power” that strengthens China’s position in the global tech landscape.
The success of DeepSeek’s AI Assistant, which recently surpassed ChatGPT as the top-rated free app on Apple’s U.S. App Store, is a testament to the power of this open-source approach. The app’s popularity underscores the global demand for advanced, affordable AI tools and highlights the growing influence of DeepSeek in the tech world.
Navigating Export Controls and Resource Limitations
Despite facing considerable challenges, particularly U.S. export controls on advanced semiconductors, DeepSeek has managed to remain resilient and innovative. These export restrictions, which aim to limit China’s access to cutting-edge hardware, have been a significant hurdle for Chinese tech companies. However, DeepSeek has found ways to work around these limitations by using less advanced chips and optimising its training methods. This ingenuity has enabled DeepSeek to develop high-performing AI models that rival those produced by U.S. companies, demonstrating that superior AI does not necessarily require the most advanced hardware.
Liang’s ability to navigate these export controls is a reflection of his resourcefulness and his commitment to advancing China’s AI capabilities regardless of external obstacles. This resilience is a crucial component of DeepSeek’s strategy to become a leader in the global AI industry and challenge the dominance of U.S. tech giants.
Liang’s Vision: A Culture of Curiosity and Innovation
Liang’s vision for China’s AI future goes beyond merely creating powerful technology. He aims to cultivate a culture of curiosity and innovation within China’s tech sector. He believes that innovation should not be driven solely by business considerations; it also requires a deep sense of curiosity and a desire to create. In this sense, Liang is advocating for a fundamental shift in China’s approach to technology—from a focus on rapid commercialisation to a more balanced emphasis on original research and development.
Liang’s belief in the importance of fundamental R&D is also evident in DeepSeek’s commitment to solving some of the most challenging problems in AI. By pursuing long-term, groundbreaking research rather than focusing solely on short-term commercial applications, Liang is positioning DeepSeek as a company that is not just building technology but also advancing the field of AI itself.
Looking to the Future
Liang Wenfeng’s leadership at DeepSeek marks a transformative moment for China’s AI development. By prioritising innovation, embracing open-source principles, and overcoming resource constraints, DeepSeek is poised to play a critical role in reshaping the global AI landscape. Liang’s strategic direction not only challenges the existing paradigms but also sets the stage for a more competitive and inclusive technological future. As DeepSeek continues to push the boundaries of AI, it is clear that Liang’s vision for China’s AI future is one of global prominence and technological leadership.
In 2024, whiskey emerged as one of the most iconic cultural symbols, not just in bars but in music as well. From genre-blending hits to celebrity-backed whiskey brands, the spirit of whiskey became synonymous with both escapism and celebration amid a turbulent year. Tracks like Shaboozey’s “A Bar Song (Tipsy),” Hozier’s “Too Sweet,” and Moneybagg Yo’s “Whiskey Whiskey” showcased whiskey as a central theme, elevating it beyond a mere drink to a key element of musical storytelling. As these hits soared through the charts, whiskey became a metaphor for navigating life’s highs and lows, perfectly capturing the spirit of 2024.
The surge in whiskey-themed music can be traced to more than just creative expression—2024 marked a time when whiskey was more than a drink; it was a moment of reflection and release. With the world facing challenges like economic instability, global conflicts, and social shifts, whiskey became the cultural antidote. These musical hits reflected the times, with whiskey as a symbol of both sorrow and celebration.
In parallel, celebrity involvement in the whiskey industry reached new heights in 2024. High-profile figures in the entertainment industry, such as Matthew McConaughey with his Longbranch whiskey, Nick Offerman’s Lagavulin, and other notable stars, introduced their own brands, driving the whiskey market to unprecedented levels of popularity. These collaborations further embedded whiskey into mainstream culture and helped shape it as one of the top spirits of the year.
The rise of whiskey can also be tied to World Whiskey Day, which is celebrated every year on the third Saturday of May. In 2024, this day of celebration on May 18th coincided with the whiskey music explosion, adding to the cultural momentum. Whiskey, a spirit deeply tied to tradition and history, took on new layers of meaning in 2024, both as a drink to savor and as a symbol of defiance, release, and indulgence.
Top Whiskeys to Try in 2024
- Heaven’s Door Whiskey: A premium whiskey from the legendary Bob Dylan, offering a rich, complex flavor that has won multiple awards. Its different variations, including straight bourbon and rye, continue to be crowd favorites.
- Kikori Whiskey: This Japanese whiskey, made from 100% rice, stands out for its smooth taste, aged in a variety of casks, including French oak and sherry. It’s one of the first whiskeys crafted by an Asian American woman.
- Four Roses Small Batch: A beautifully smooth bourbon with hints of caramel and cherry, Four Roses Small Batch is a favorite for those seeking a slightly sweeter option.
- Redbreast 21 Years Old: Known for its rich and creamy honeyed flavors, Redbreast was named the best Irish whiskey for 2024 by the World Whiskey Awards.
The rise of whiskey as both a drink and a cultural symbol shows no signs of slowing down. Music, spirits, and celebrity collaborations created a perfect storm that made 2024 a defining year for whiskey. Whether you’re celebrating World Whiskey Day or simply enjoying a night out, whiskey’s influence on pop culture will continue to resonate in the years to come.
As the year wraps up, the whiskey trend shows no signs of fading, and it’s clear that this spirit will continue to be at the center of musical hits, cultural moments, and global celebrations.
Health & Wellness
Discover Sublime Elegance with Tory Burch’s Latest Fragrance, Inspired by Kendall Jenner
Fragrance has always been a personal expression, a scent that lingers and defines the wearer’s identity. Tory Burch’s latest fragrance, a sublime creation, brings together elegance and allure, capturing the essence of modern femininity. Known for her sophisticated designs and luxurious aesthetic, Tory Burch has taken her expertise to the world of fragrance, collaborating with supermodel Kendall Jenner to introduce a new scent that is destined to become iconic.
In this blog, we explore Tory Burch’s latest fragrance, its unique ingredients, and why it’s the perfect addition to your perfume collection.
A Sublime Creation: Tory Burch’s Latest Fragrance
When you think of Tory Burch, you likely envision timeless elegance, bold designs, and an effortless sense of style. Her new scent is no different, perfectly capturing the essence of what her brand represents. The fragrance is a sublime fusion of floral and woody notes, creating a sophisticated yet warm aroma that’s as inviting as it is memorable.
This sublime fragrance is designed to evoke a sense of confidence and femininity, with an underlying warmth that makes it suitable for both day and night wear. Its blend of unique ingredients ensures that it lasts throughout the day, leaving a lingering presence that captivates those around you.
Kendall Jenner: The Face of Tory Burch’s New Scent
In the launch of Tory Burch’s latest fragrance, Kendall Jenner, one of the most influential supermodels of our time, takes center stage as the face of the campaign. Known for her grace and beauty, Kendall perfectly embodies the spirit of the fragrance—modern, confident, and effortlessly chic.
Jenner’s presence brings an added layer of glamour and allure to the new scent, creating a seamless connection between the fragrance and the world of high fashion. As a close collaborator with Tory Burch, Kendall’s personal style and influence add an authentic touch to the fragrance, making it all the more captivating for perfume enthusiasts and fashion fans alike.
What Makes Tory Burch’s Latest Fragrance Unique?
Tory Burch’s latest fragrance is not just another perfume. It’s a celebration of femininity, designed to resonate with women who embrace their strength, individuality, and timeless beauty. Here’s what sets this sublime fragrance apart:
- Floral and Woody Notes: The fragrance opens with bright citrus and lush floral notes, like peony and jasmine, before revealing a rich base of warm woods and creamy sandalwood. This balanced composition makes it ideal for women who want a scent that feels both fresh and enduring.
- Longevity and Versatility: What makes this fragrance special is its staying power. The scent lingers long after application, ensuring you remain enveloped in its beauty throughout the day. Whether you’re heading to a brunch or an evening event, this fragrance adapts to your lifestyle effortlessly.
- Chic and Modern Design: True to Tory Burch’s style, the bottle is sleek, elegant, and instantly recognizable. The minimalist design, combined with a touch of luxury, makes it a perfect addition to any vanity or perfume collection.
How to Wear Tory Burch’s New Scent
To make the most of Tory Burch’s latest fragrance, here are a few tips on how to wear it:
- Layering: Apply the fragrance to your pulse points—wrists, neck, and behind your ears. This will help the scent bloom throughout the day.
- Pairing with Fashion: Like Kendall Jenner, pair this fragrance with elegant pieces from Tory Burch’s collection to complete your sophisticated look.
- Day or Night: This fragrance is versatile enough for any occasion, whether you’re heading to a meeting, a lunch date, or a glamorous evening out.
Final Thoughts
Tory Burch’s new scent, crafted with elegance and a touch of modernity, offers a truly sublime fragrance experience. With Kendall Jenner as the face of this luxurious creation, it’s clear that this fragrance is destined to become a staple for women who appreciate high-end fashion and sophisticated scents. Whether you’re a long-time fan of Tory Burch or a fragrance aficionado seeking something fresh, this new scent will surely capture your heart.
If you’re looking to add a touch of elegance to your scent collection, Tory Burch’s latest fragrance is a must-try.
-
Health4 years agoEva Savagiou Finally Breaks Her Silence About Online Bullying On TikTok
-
Health3 years agoTraumatone Returns With A New EP – Hereafter
-
Health3 years agoTop 5 Influencers Accounts To Watch In 2022
-
Fashion4 years agoNatalie Schramboeck – Influencing People Through A Cultural Touch
-
Fashion4 years agoThe Tattoo Heretic: Kirby van Beek’s Idea Of Shadow And Bone
-
Fashion8 years ago9 Celebrities who have spoken out about being photoshopped
-
Health4 years agoTop 12 Rising Artists To Watch In 2021
-
Tech2 years agoGoogle Developer Conference to Unveil Latest AI Updates, Including PaLM 2 Language Model
-
Health4 years agoBrooke Casey Inspiring People Through Her Message With Music
-
Health3 years agoTop 10 Influencers To Follow This 2021